This paper describes a test program that was developed to measure the dynamic response of a bundle of steam generator U-tubes with anti-vibration bar (AVB) supports, subjected to Freon two-phase cross-flow. The tube bundle geometry is similar to the geometry used in preliminary designs for future CANDU steam generators. This test program is one of the initiatives that Atomic Energy of Canada Limited (AECL) is undertaking to demonstrate that the tube support design for future CANDU steam generators meets the stringent requirements associated with a 60-year lifetime. In particular, the tests will address issues related to in- and out-of-plane fluidelastic instability and random turbulent excitation of a U-tube bundle with AVB supports. Therefore, the measurements include tube vibration amplitudes and frequencies, work-rate due to impacting and sliding motion of the tubes against their supports, bulk process conditions and local two-phase flow properties. Details of the test rig setup and the measurement techniques are described in the paper. Moreover, a numerical prediction of the U-tube vibration response to flow was performed with AECL’s pipo-fe code. A summary of the numerical results is presented.