Bolted flange joints are extensively used to connect pressure vessels and piping equipment together. They are simple structures that offer the possibility of disassembly. However, they often experience leakage problems due to a loss of tightness as a result of a nonuniform distribution of gasket contact stresses in the radial and circumferential direction. Many factors contribute to such a failure; the flange and gasket stiffness and bolt spacing design combination being one of them. In our recent paper, the effects of bolt spacing were investigated based on the theory of circular beams resting on a linear elastic foundation (Do, T. D., Bouzid, A. H., and Dao, T.-M., 2011, “Effect of Bolt Spacing on the Circumferential Distribution of Gasket Contact Stress in Bolted Flange Joints,” ASME J. Pressure Vessel Technol., 133 (4), 041205). This paper is an extension of the work in which an analytical solution based on the real nonlinear gasket behavior is developed. This study focuses on the distribution of the gasket contact stress of two large diameter flanges, namely, a 52 in. and a 120 in. heat exchanger (HE) flanges. The nonlinear gasket behavior solution is compared to the Finite Element Analysis (FEA) and the linear gasket behavior solution for evaluation and comparison.