A new lifetime criterion for withdrawal of turbine components from service is developed in this paper based on finite element (FE) analysis and experimental results. Finite element analysis is used to determine stresses in the turbine component during the imposed cyclic loads and analytically predict a fatigue life. Based on the finite element analysis, the critical section is then subjected to a creep-fatigue test, using three groups of full scale turbine components, attached to an actual turbine disc conducted at 750 °C. The experimental data and life prediction results were in good agreement. The creep-fatigue life of this type of turbine component at a 99.87% survival rate is 30 h.