Having previously verified the quasi-steady model under two-phase flow laboratory conditions, the present work investigates the feasibility of practical application of the model to a prototypical steam generator (SG) tube subjected to a nonuniform two-phase flow. The SG tube vibration response and normal work-rate induced by tube-support interaction are computed for a range of flow conditions. Similar computations are performed using the Connors model as a reference case. In the quasi-steady model, the fluid forces are expressed in terms of the quasi-static drag and lift force coefficients and their derivatives. These forces have been measured in two-phase flow over a wide range of void fractions making it possible to model the effect of void fraction variation along the tube span. A full steam generator tube subjected to a nonuniform two-phase flow was considered in the simulations. The nonuniform flow distribution corresponds to that along a prototypical steam-generator tube based on thermal-hydraulic computations. Computation results show significant and important differences between the Connors model and the two-phase flow based quasi-steady model. While both models predict the occurrence of fluidelastic instability, the predicted pre-instability and post instability behavior is very different in the two models. The Connors model underestimates the flow-induced negative damping in the pre-instability regime and vastly overestimates it in the post instability velocity range. As a result the Connors model is found to underestimate the work-rate used in the fretting wear assessment at normal operating velocities, rendering the model potentially nonconservative under these practically important conditions. Above the critical velocity, this model largely overestimates the work-rate. The quasi-steady model on the other hand predicts a more moderately increasing work-rate with the flow velocity. The work-rates predicted by the model are found to be within the range of experimental results, giving further confidence to the predictive ability of the model. Finally, the two-phase flow based quasi-steady model shows that fluidelastic forces may reduce the effective tube damping in the pre-instability regime, leading to higher than expected work-rates at prototypical operating velocities.