Many recent studies have emphasized the need for improving seismic performance of nonstructural systems in critical facilities in order to reduce the damage as well as to maintain continued operation of the facility after an earthquake. This paper is focused on evaluating system-level seismic fragility of the piping in a representative high-rise building. Piping fragilities are evaluated by incorporating the nonlinear finite-element model of a threaded Tee-joint that is validated using experimental results. The emphasis in this study is on evaluating the effects of building performance on the piping fragility. The differences in piping fragility due to the nonlinearities in building are evaluated by comparing the fragility curves for linear frame and nonlinear fiber models. It is observed that as nonlinearity in the building increases with increasing value of peak ground acceleration, the floor accelerations exhibit a reduction due to degradation/softening. Consequently, the probabilities of failure increase at a slower rate relative to that in a linear frame. It is also observed that a piping located at higher floor does not necessarily exhibits high fragilities, i.e., the fundamental building mode is not always the governing mode. Higher order building modes with frequencies closest to critical piping modes of interest contribute more significantly to the piping fragility. Within a particular building mode of interest, a good indicator of the amplification at different floor levels can be obtained by the product of mode shape ordinate and modal participation factor. Piping fragilities are likely to be higher at floor levels at which this product has a higher value.